The article correlates the results of informative investigation of bio-availability of selected elements in the surrounding of Banská Štiavnica using the method of five-staged sequential analyses of technogenous, creek and bottom land sediments. It also presents the correlation of laboratory modeling of hydroquartzite and sand samples (from the tailings dam) of percolation and static maceration of heavy minerals by acid metal-rich sulphate water. Results are documented in tables, plots and diagrams. The sequential analyses showed that from the selected elements a high portion of Mn, Cu, Zn, Pb, and Cd elements is presented in bio-available forms and low portion of bio-available As, Sb and Hg in bondings. Chemical changes in technogenous sediments attended by microorganisms modify also the mineral composition of sediments of mining dumps and settling pits. Bio-oxidation processes product both inorganic and organic acids that are decomposing quartz and aluminosilicate minerals. Aluminosilicates are formed primary at interest of quartz from clay minerals.