Long-term monitoring of groundwater regimes has been conducted to study the impact of prolonged groundwater abstraction from an aquifer in northern Serbia (Bačka District). This aquifer within the Pannonian Basin represents the principal source of drinking water supply. In general, the quality of the groundwater used as the drinking water supply in this region is not satisfactory. The quality of raw water is analysed. Groundwater temperature is in range of 14 and 24ºC, while turbidity is between 0.3 and 9.3 NTU. The chemical parameters that have elevated concentrations include the ammonium ion (0.05 – 0.4 mg/L), iron (0.05 – 3 mg/L), arsenic (10 – 210 μg/L) and KMnO4 demand (4 – 195 mg/L). The dissolved solid content of waters in some locations exceeds 1000 mg/L. A hydrodynamic model was used to study the effects of current groundwater abstractions. The scenarios that were assessed reflected reduced precipitation and different rates of groundwater abstraction. The outcomes presented in this paper, have contributed creating a clearer picture of the hydrogeological characteristics of this part of the Pannonian Basin and provided insight into the conditions for more robust management of this groundwater resource.